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KMID : 1161920190160030055
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Journal of Medicine and Life Science
2019 Volume.16 No. 3 p.55 ~ p.59
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Physiological approach of CADASIL animal model and its predictable implication
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Jung Sung-Cherl
Ko Eun-A
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Abstract
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Cerebral vessels are functionally and structurally specialized to provide adequate blood flow to brain which shows high metabolic rates. Cerebral hemorrhage or ischemic infarction due to cerebrovascular injury or occlusion can cause the immediate brain damage, and if not treated rapidly, can lead to serious or permanent brain damages, and sometimes life-threatening. Unlike these popular cerebrovascular diseases, there are diseases caused by genetic problems. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of them. CADASIL does not show the high incidence, but it is considered to be significantly affected by regional obstructiveness such as islands and therefore, to be an important genetic disease in Jeju. This paper aims to summarize the possibility of animal model research that can provide preclinical data for CADASIL disease research and to evaluate its applicability in future research plans.
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KEYWORD
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CADASIL, Animal model, Cerebral blood flow, K+ channel, Ca2+ channel
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